Spheroform: therapeutic spheroid-forming nanotextured surfaces inspired by desert beetle Physosterna cribripes

Mihyun Lee; Kisuk Yang; Yong Hwa Hwang; Youngro Byun; Dong Yun Lee; Seung-Woo Cho; Haeshin Lee

doi:10.1002/adhm.201400429

Spheroform: therapeutic spheroid-forming nanotextured surfaces inspired by desert beetle Physosterna cribripes

Adv Healthc Mater. 2015 Mar 11;4(4):511-5. doi: 10.1002/adhm.201400429. Epub 2014 Oct 17.

Authors

Mihyun Lee¹, Kisuk Yang, Yong Hwa Hwang, Youngro Byun, Dong Yun Lee, Seung-Woo Cho, Haeshin Lee

Affiliation

¹ Department of Chemistry, Center for Nature-inspired Technology in KINC, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Republic of Korea.

PMID: 25323327
DOI: 10.1002/adhm.201400429

Abstract

An approach is presented to create arrays of quasi-spherical microdroplets by surfaces called "spheroform" inspired by micro-/nanostructures found in the back of the Namib desert beetle. Spheroform is fabricated by microarray formation of catecholamine polymers on the superhydrophobic background. Spheroform is able to precisely control spheroid sizes of therapeutic islet cells and mesenchymal stem cells. The therapeutic spheroids exhibit improved biochemical activities.

Keywords: desert beetles; islet cells; mesenchymal stem cells; polydopamine; therapeutic spheroids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biomimetic Materials / therapeutic use*
Coleoptera / anatomy & histology*
Humans
Islets of Langerhans / cytology
Mesenchymal Stem Cells / cytology
Nanostructures / therapeutic use*
Spheroids, Cellular / cytology*
Surface Properties